Discoveries regarding the importance of pathways in cancer have resulted in a change in cancer treatments from conventional chemotherapy and radiation therapy to a molecular targeted approach to treatment. Personalized medicine is a rapidly growing field in which healthcare providers can determine appropriate pharmacotherapy for cancer patients by using the genetic markers within their tumor DNA. Further, the session inspired their interest in learning more about pharmacogenomics and their professional roles in personalized medicine. The pharmacogenomic laboratory exercise prepared students to understand how genetic markers give clinical insight into the appropriate application of drugs in oncology pharmacotherapy.
In a postintervention survey, students highly rated the effectiveness of the laboratory session for learning pharmacogenomics, and subsequent examination scores reflected retention of principles and understanding of clinical application.Ĭonclusion. Using polymerase chain reaction (PCR) and high-resolution melting analysis of deoxyribonucleic acid (DNA) from colorectal cancer cell lines to determine the presence of somatic mutations for an oncogenic marker, students formulated the proper course of treatment for a patient with similar tumor genomics.Īssessment. To teach first-year (P1) pharmacy students to apply the principles of pharmacogenomics underlying clinical pharmacotherapeutics to cancer patients.ĭesign.
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